Absence of cross-reactivity between murine Ly-6C and Ly-6G

Expressed by B Lymphocytes and Ly-6i Recognize Two Potential Ligands Ly-6 Superfamily Members Ly-6a/e, Ly-6c

Plasticity of Ly-6C Myeloid Cells in T Cell Regulation

CD11b + Ly-6C hi cells, including inflammatory monocytes (IMCs) and inflammatory dendritic cells (IDCs), are important in infectious , autoimmune, and tumor models. However, their role in T cell regulation is controversial. In this article, we show that T cell regulation by IMCs and IDCs is determined by their activation state and is plastic during an immune response. Non-activated IMCs and IDC...

CD11b+Ly-6C(hi) suppressive monocytes in experimental autoimmune encephalomyelitis.

Innate immune cells may regulate adaptive immunity by balancing different lineages of T cells and providing negative costimulation. In addition, CD11b(+)Gr-1(+) myeloid-derived suppressor cells have been described in tumor, parasite infection, and severe trauma models. In this study, we observe that splenic CD11b(+) cells markedly increase after experimental autoimmune encephalomyelitis (EAE) i...

Extramedullary Hematopoiesis Generates Ly-6C Monocytes That Infiltrate Atherosclerotic Lesions

Background—Atherosclerotic lesions are believed to grow via the recruitment of bone marrow–derived monocytes. Among the known murine monocyte subsets, Ly-6C monocytes are inflammatory, accumulate in lesions preferentially, and differentiate. Here, we hypothesized that the bone marrow outsources the production of Ly-6C monocytes during atherosclerosis. Methods and Results—Using murine models of ...

CD11b Ly-6C Suppressive Monocytes in Experimental Autoimmune Encephalomyelitis